Part 3 of our A Practical Guide to Planning a Cryogenic Storage Facility Series In our previous blog post, we uncovered key safety considerations and why monitoring your LN2 facility and storage units is imperative in ensuring the safety of your facility. In this part of our blog series, we lay out the key factors to […]
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Part 2 of our Protecting Complete Chain of Custody Series As we discussed in our last post, the Role of Biobanking in Protecting Sample Chain of Custody, biobanks serve as biospecimen libraries as well as sample data, validation, and reference sources for both research and clinical labs. Like any part of a controlled process, establishment of a quality […]
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Part 2 of our A Practical Guide to Planning a Cryogenic Storage Facility Series In our previous post, we covered several key considerations for selecting the appropriate space and equipment when designing your cryogenic storage facility. In this post, we will highlight how to ensure the safety of your facility. Did you know that a proper […]
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Part 1 of our Protecting Complete Chain of Custody Series As key components of the research ecosystem, biobanks share a vital function and critical responsibility in the protection of biospecimens. They are centralized members in the chain of custody for samples, and as such, have an impact on both upstream and downstream portions of the molecular biologist’s […]
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Part 1 of our A Practical Guide to Planning a Cryogenic Storage Facility Series Storing biological materials, especially living cells and tissues, can be a complicated process. Improper handling or storage conditions can damage cells, reducing viability and compromising their utility in downstream applications. Keeping specimens below -135°C, the glass transition temperature (Tg) of water, […]
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Safe and efficient storage of samples—whether chemical, biological, or clinical—is an integral, yet sometimes overlooked, part of laboratory work from drug discovery to clinical trials. The goal is straightforward: faithfully preserve materials for later use or analysis. The execution can be notably trickier, especially as collections grow and the tracking and movement of samples becomes […]
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RNA sequencing (RNA-Seq) is a powerful method for studying the transcriptome qualitatively and quantitatively; it can be used to identify the full catalog of transcripts, precisely define the structure of genes, and accurately measure gene expression levels. Traditional RNA-Seq approaches typically require at least 10,000 cells or 500 ng of total RNA per sample. For […]
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Manufacturing and distribution of advanced therapies relies on stable low temperatures. Cellular products and other biological materials are often stored below -135°C, the glass transition temperature of water (Tg), where enzymatic activity is believed to cease. Routine handling in and out of storage can expose materials to temperatures above Tg, leading to degradation and reduced […]
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As cell and gene therapies (CGT) advance into the clinical stage, many cold chain complexities arise not only for these novel products but also for the biological samples that must be collected from patients during clinical trials. Managing these sensitive materials—including storage, transportation, and tracking—requires robust and adaptable systems to ensure safety, integrity, and regulatory […]
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CAR T-Cell Therapy is Giving Patients Hope for the Future In 2010, Emily Whitehead was diagnosed with lymphoblastic leukemia. Just five-years old, she received chemotherapy—the best available treatment at the time. When her cancer returned in 2011, Emily became the first child in the world to receive an experimental CAR T-cell therapy. This innovative approach […]
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