Cryopreservation extends the viability of cells by cooling them to extremely low temperatures and thus keeping them in a safe, biochemically inactive state. This process gives much-needed flexibility to researchers and those developing cell-based therapies. The latter involves collecting living cells from donors, transporting them to manufacturing sites for processing or screening, and then delivering […]
View Blog
When Pfizer initially released its COVID-19 mRNA vaccine, distributing it was a major challenge. Scientists thought that the vaccine had to be stored at -70°C, requiring dry ice or ultra-cold freezers. At scale, explains David Lewandowski, Azenta’s Strategic Partnerships Manager for Automated Storage, “Temperature matters. The warmer it is, the easier it is [to deliver […]
View Blog
Azenta Launches CryoArc™ Pico at SLAS2023 Many cell and gene therapies today rely on cryostorage with precise cold chain handling to ensure the viability and effectiveness of the cells that deliver life-saving treatments. But accessing these cell therapies can sometimes be a cumbersome process for labs and clinics that don’t have the space needed to […]
View Blog
Manufacturing and distribution of advanced therapies relies on stable low temperatures. Cellular products and other biological materials are often stored below -135°C, the glass transition temperature of water (Tg), where enzymatic activity is believed to cease. Routine handling in and out of storage can expose materials to temperatures above Tg, leading to degradation and reduced […]
View Blog
As cell and gene therapies (CGT) advance into the clinical stage, many cold chain complexities arise not only for these novel products but also for the biological samples that must be collected from patients during clinical trials. Managing these sensitive materials—including storage, transportation, and tracking—requires robust and adaptable systems to ensure safety, integrity, and regulatory […]
View Blog
CAR T-Cell Therapy is Giving Patients Hope for the Future In 2010, Emily Whitehead was diagnosed with lymphoblastic leukemia. Just five-years old, she received chemotherapy—the best available treatment at the time. When her cancer returned in 2011, Emily became the first child in the world to receive an experimental CAR T-cell therapy. This innovative approach […]
View Blog