In biological storage, freeze-thaw cycles are considered to be a significant cause of analyte loss. In compound management, single use microtubes are well established as a way to minimize the water content of compounds dissolved in DMSO, as well as any precipitation of compounds from the solution.
The sealing material is first placed in position over the plate. Heat is applied evenly for several seconds, resulting in welding of the sealing material and the plate. This achieves a complete seal without the need for adhesives, which can interfere with the sample. Heat sealing is a proven technology that offers a number of advantages over other plate sealing methods.
Due to the rapid nature of heat sealing, the temperature of samples within the wells does not rise significantly during sealing. Therefore, even temperature sensitive samples, such as enzymatic reactions, are not affected during the sealing step.